Melatonin-Free Sleep Formula

Sleepy-Biome

Your gut talks to your brain — especially at night. Sleepy-Biome works along the gut–brain axis, combining three probiotic strains with GABA, L-Theanine, 5-HTP and a triple-herbal complex for calm, restorative nights.*

Melatonin-Free 3 Billion CFU 3 Probiotic Strains 60 Capsules · 30 Servings Vegan · Non-GMO
Sleepy-Biome melatonin-free probiotic sleep formula — 60 capsules
Why Sleepy-Biome

Three layers of night-time support*

Most sleep supplements do one thing. Sleepy-Biome works on three fronts at once — the microbiome, the calming neurotransmitters, and the herbs that help you wind down.

Gut–Brain Axis Support

The microbiome layer

Three probiotic strains — L. brevis, B. bifidum and L. rhamnosus — support serotonin and GABA pathways for balanced, restorative rest.*

Melatonin-Free Calm

The neurotransmitter layer

GABA, L-Theanine and 5-HTP work together to quiet the mind and ease stress — naturally, and without melatonin.*

Triple-Herbal Complex

The botanical layer

Valerian root, lavender and lemon balm extracts support sleep quality and deep relaxation, with ashwagandha for evening stress balance.*

What it does

Sleep deeply. Wake rested. Feel calm.*

Melatonin-Free & Non-Habit Forming

Supports your body's own wind-down rhythm rather than overriding it with a hormone.*

Deep, Restorative Sleep

Formulated to support sleep quality through the night, not just help you drift off.*

Gut–Brain Axis Balance

The only sleep formula in our range built around the conversation between gut and brain.*

Eases Nighttime Tension

Ashwagandha and the herbal complex help settle evening stress before it reaches your pillow.*

Wake Without the Fog

Designed for calm nights and clear mornings — no groggy hangover feeling.*

Vegan, Gluten-Free, Non-GMO

Plant-based capsules made in the USA under strict GMP standards.

The microbiome layer

Three strains, 3 billion CFU

A focused probiotic blend chosen for the gut–brain axis rather than digestion alone.

Levilactobacillus brevis

Studied for its role in GABA-related pathways in the gut.*

Bifidobacterium bifidum IDCC 4201R

A foundational Bifidobacterium supporting beneficial gut flora.*

Lactobacillus rhamnosus SP1

One of the most researched strains for gut and everyday wellness.*

Calm actives & botanicals

What quiets the mind

Valerian root, lavender, lemon balm and ashwagandha

GABA 120 mg

The body's main calming neurotransmitter — supports a quiet mind before bed.*

L-Theanine 100 mg

From tea leaves — promotes relaxed alertness that settles into rest, without sedation.*

Valerian Root 100 mg

Standardized extract, long used to support sleep quality and deep relaxation.*

5-HTP 50 mg

A precursor the body uses in serotonin pathways, supporting mood and rest.*

Lavender Flower 40 mg

Calms tension and supports a peaceful transition into sleep.*

Lemon Balm 30 mg

A traditional evening herb for relaxation and everyday calm.*

Ashwagandha Root 20 mg

An adaptogen that helps balance evening stress for deeper rest.*

Full transparency

What's inside every serving

Supplement FactsAmount Per Serving
Serving Size: 2 capsulesServings Per Container: 30
Vitamins & Minerals
Vitamin B6 as pyridoxine HCl
2.5 mg147% DV
Magnesium as magnesium bisglycinate
15 mg4% DV
Calm Actives & Botanicals
Gamma-aminobutyric acid (GABA)
120 mg
L-Theanine
100 mg
Valerian root standardized extract
100 mg
5-Hydroxytryptophan (5-HTP)
50 mg
Lavender flower
40 mg
Lemon balm extract aerial parts
30 mg
Ashwagandha root extract
20 mg
Probiotic Blend
Probiotic BlendBifidobacterium bifidum IDCC 4201R · Lactobacillus rhamnosus SP1 · Levilactobacillus brevis
40 mg3 Billion CFU
* Daily Value not established.  ·  Other ingredients: Algolithe P® (calcified red algae, non-GMO maize starch), capsule (hypromellose, gellan gum), vegetable magnesium stearate, and silica.  ·  60 capsules per bottle.
Why choose it

A different approach to sleep

See how Sleepy-Biome compares to a standard melatonin sleep aid.

Sleepy-Biome

  • Melatonin-free and non-habit forming
  • 3 probiotic strains · 3 billion CFU
  • GABA, L-Theanine & 5-HTP
  • Valerian, lavender, lemon balm & ashwagandha
  • Works along the gut–brain axis
  • Vegan, gluten-free, non-GMO

A standard melatonin aid

  • Usually a single hormone ingredient
  • No probiotic or microbiome support
  • No calming amino acids
  • Rarely includes a herbal complex
  • Targets timing only, not the gut–brain axis
  • Some users report morning grogginess
Sleep better tonight

And every night after

Good sleep isn't a single night — it's a rhythm you build. Take Sleepy-Biome 30–60 minutes before bed and let it become the signal that the day is closing.*

Because it's melatonin-free, it works with your own wind-down process rather than overriding it — which is what makes it suitable for a nightly routine.*

Calm bedside scene at night with lavender and a warm lamp
Simple nightly ritual

How to use

Adults take 2 capsules with water, 30–60 minutes before bedtime.

2 capsules with water

One serving is two capsules — 30 servings per bottle.

30–60 minutes before bed

Give the formula time to work as you start winding down.

Pair it with a wind-down

Dim the lights, put the screens away — the routine matters as much as the capsule.

Stay consistent

Use nightly for best results. Store in a cool, dry place with the lid tightly sealed.

Important: For adults only. Not for children, or for pregnant or nursing women. Do not exceed the recommended dose. If you are taking any medication — particularly antidepressants or other medicines that affect serotonin — or if you have a medical condition, consult your doctor before use. Do not drive or operate machinery after taking it.
Made responsibly

Quality you can trust

Made in the USAFDA-registered facility
GMP CertifiedGood Manufacturing Practice
Gluten FreeNo gluten ingredients
Non-GMONon-GMO ingredients
VeganPlant-based capsules
Good to know

Frequently asked questions

How and when do I take Sleepy-Biome?
Adults take 2 capsules with water, 30–60 minutes before bedtime. Each bottle holds 60 capsules — 30 servings, so a 30-night supply.
Why is it melatonin-free?
Melatonin is a hormone that signals timing. Sleepy-Biome takes a different route: it supports the pathways your body already uses to wind down — through the gut–brain axis, calming amino acids and traditional sleep herbs — which is why it's suitable as a nightly routine and non-habit forming.*
What does the gut–brain axis have to do with sleep?
Your gut and brain communicate constantly, and much of that conversation involves the same messengers used in rest and mood — serotonin and GABA among them. The three probiotic strains in Sleepy-Biome were chosen to support those pathways, which is what makes this a sleep formula rather than a digestive one.*
Will I feel groggy in the morning?
The formula is designed for calm nights and clear mornings rather than heavy sedation. That said, everyone responds differently — try your first dose on a night when you don't need to be up early, and don't drive or operate machinery after taking it.
Can I take it with my medication?
Check with your doctor first. This is especially important if you take antidepressants or any other medicine that affects serotonin, because the formula contains 5-HTP, which can interact with them. The same applies if you take sedatives, or if you have any medical condition. Your healthcare provider knows your history and is the right person to advise you.
How long until I notice a difference?
Some people notice a calmer wind-down within the first several nights. The microbiome side works more gradually, so give it a few weeks of consistent nightly use before judging the full effect.*
Does it need to be refrigerated?
No. Store it in a cool, dry place with the lid tightly sealed, out of reach of children.
Who should not take it?
Sleepy-Biome is for adults only. It is not for children, or for women who are pregnant or nursing. If you have an ongoing sleep problem — trouble sleeping most nights for several weeks, or sleep that leaves you exhausted during the day — that's worth raising with a doctor rather than managing with a supplement alone.

Algolithe P® is a registered trademark of its manufacturer.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This product is not a substitute for medical advice.