Human Microbiome Hub

Your Complete Guide to Microbes, Immunity, Digestion & the Oral–Gut–Brain Axis

The human microbiome is not just a trend — it’s one of the most important discoveries in modern biology. Trillions of microorganisms living in and on your body continuously shape:

• digestion

• gut lining integrity

• immunity & inflammation

• metabolism

• oral health

• mood, stress & cognition

• long-term disease risk

This Human Microbiome Cluster brings together 5 core articles written by microbiome scientist Ali Rıza Akın, designed to guide your readers from foundational understanding to cutting-edge innovations.

1️⃣ Start Here: What Is the Human Microbiome?

👉 What Is the Human Microbiome? A Complete Guide to Microbes, Immunity & Digestion

This pillar article explains:

• what the human microbiome is

• where microbes live (gut, mouth, skin, lungs, reproductive tract)

• how they support digestion, immunity, and gut barrier health

• how SCFAs, mucin, and microbial diversity influence overall health

• foundational references like the Human Microbiome Project

Use this as the main “educational entry point” for new visitors.

2️⃣ The Mouth Comes First: Oral Microbiota & Gut Health

👉 Oral Microbiota & Gut Health: How the Mouth Shapes the Entire Microbiome

This article covers:

• what the oral microbiota is

• how more than 1 billion oral bacteria migrate into the gut every day

• how oral dysbiosis can trigger gut dysbiosis and inflammation

• why the oral–gut axis is critical for digestion and immunity

• why chewable formulations have an advantage over capsules

Ideal for tying in oral–gut formulations and your chewable synbiotics.

3️⃣ Mind–Gut Link: The Gut–Brain Axis

👉 The Gut–Brain Axis: How Microbes Influence Mood, Stress, Appetite & Mental Well-Being

This blog explains:

• what the gut–brain axis is

• how microbes affect serotonin, dopamine, GABA, and stress response

• how dysbiosis contributes to anxiety, cravings, poor sleep, and low mood

• the interplay between oral microbes, gut microbes, and the vagus nerve

• how polyphenols, SCFAs, and gut-lining integrity all contribute to mental health

Great for connecting microbiome support to mood, stress & appetite.

4️⃣ Origins: Microbiome Development From Birth to Adulthood

👉 Microbiome Development From Birth to Adulthood: How Early Life Shapes Lifetime Health

This article explores:

• how microbiota colonization begins at birth

• differences between vaginal birth vs. C-section

• the role of breastfeeding, HMOs (2’-FL), and early diet

• how early-life disruptions (antibiotics, environment, feeding) shape lifelong immunity and metabolic risk

• how microbiome development continues through childhood, adolescence, and aging

Perfect for parent education, early-life support positioning, and explaining why prevention starts early.

5️⃣ What’s Next: Microbiome Innovations & Future Science

👉 Microbiome Innovations & The Future of Microbial Science: What’s Coming Next

This future-facing article covers:

• next-generation probiotics (Akkermansia, Christensenella, C. butyricum)

• mucin-layer repair and gut barrier therapeutics

• oral–gut-focused interventions

• SCFA biology and precision microbial therapies

• microbiome-based precision nutrition and AI-guided personalization

• microbiome innovations in sustainability and environmental health

✍️ About the Author

All articles in this cluster are written by:

Ali Rıza Akın
Microbiome Scientist, Author & Founder of Next-Microbiome

Ali Rıza Akın is a microbiome scientist with nearly 30 years of biotechnology and translational research experience in Silicon Valley. He is the discoverer of Christensenella californii, a novel human-associated microbial species linked to mucosal and metabolic health.

His work spans:

• gut mucosal immunity & barrier biology

• oral–gut microbiome interactions

• SCFA metabolism & microbial signaling

• next-generation probiotics (Akkermansia, Christensenella, C. butyricum)

• translational microbiome therapeutics

He is the author of Bakterin Kadar Yaşa: İçimizdeki Evren and a contributor to Bacterial Therapy of Cancer: Methods and Protocols (Springer). As the Founder of Next-Microbiome, he develops advanced synbiotic formulations — including the first chewable Akkermansia-supporting synbiotic — engineered to strengthen the gut lining and harmonize the oral–gut–brain axis.